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KMID : 0383819740210030144
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Tuberculosis and Respiratory Diseases
1974 Volume.21 No. 3 p.144 ~ p.148
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Experimental study on production of Freeze Dried B.C,G, Vaccine in Korea
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신현오(申鉉五)/Huyn Oh Shin
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Abstract
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Author prepared 30 lots of Freeze dried B.C.G. Vaccine with using Stories Freeze
dryer.
The vaccine was dried for 24 hours in a vacuum of 200 micron at 25℃, after few
hours initial freezing at -40℃.
The number of viable count was determined by the quantitative culture on
L wenstein-Jensen medium.
The survival rate was 37% compared before freeze drying and the viavle rate after 3
months storage at 5℃ was 81% and 16% after 6 months.
In regard to the tuberculin conversion rate to schoolchildren, the freeze dried B.C.G.
vaccine showed 66% comparing with the wet B.C.G. vaccine which showed 76%.
And the size of average induration by the freeze dried vaccine was a little smaller than
that by the wet vaccine, the size of the vaccination lesion by the freeze dried B.C.G
vaccine was smaller then that of wet B.C.G vaccine.
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KEYWORD
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